Parkinson’s Disease

Is Angiogenesis a Treatment or Potential Cure?

Zhittya Genesis Medicine is developing a drug, fibroblast growth factor 1 (FGF-1), to possible treat Parkinson's Disease by growing new blood vessels in ischemic tissue in the brain, particularly by reestablishing blood flow in dopamine-producing parts of the brain such as the substantia nigra. 

Since May 2022, Zhittya Genesis Medicine has dosed over 196 individuals suffering from Parkinson's Disease in Medical Research Studies. Beyond demonstrating potentially impressive safety data, it has also reported improved motor scores of all Parkinson's patients in the study. Beyond improved motor scores, patients have reported non-motor improvements such as improvements in sleep quality, balance, cognition, among other qualities. 

Our Data: Graphed

MDS-UPDRS Score v. Month

The graph above shows preliminary results of our human patients' average potential motor skill improvements compared to the average decline in motor skills for individuals suffering from Parkinson's Disease over 6 months. This data could indicate that FGF-1 has the ability to improve motor skills in individuals suffering from Parkinson's Disease in this group of ~100 human participants. Please note that scores closer to 0 indicate better movement.

History

FGF-1 is a potent stimulator of angiogenesis, the growth of new blood vessels, and is capable of growing new blood vessels in ischemic areas of the body, including the brain. Research has indicated that a lack of blood perfusion to dopamine producing neurons located in the substantia nigra region of the brain lead to a lack of dopamine and the classic symptoms of Parkinson’s Disease.

In the past, FGF-1 has been able to grow new blood vessels in the human body. In a US FDA Phase IIA clinical trial, conducted at the University of Cincinnati, our drug was able to grow new blood vessels in the hearts of individuals with coronary artery disease, improving many of their symptoms.

FGF-1 has also shown excellent efficacy in treating Parkinson’s Disease in Cynomolgus monkey models. After being injected with a neurotoxin that selectively destroys dopamine-producing neurons, the two groups of monkeys came down with the classic symptoms of Parkinson’s Disease. One group was a placebo group and another was administered FGF-1, which lead to improvement in motor scores, increased dopamine production, and decreased plaque build-up.

Watch as Zhittya Genesis Medicine’s drug is used to grow new blood vessels in the human heart in a US FDA Phase IIA Clinical Trial done at the University of Cincinnati, and reported by ABC Nightly News. Zhittya believes that by growing new blood vessels in the human brain, that the symptoms of Parkinson’s Disease can be alleviated.

Watch our theory of how we believe FGF-1 can be used to treat Parkinson’s Disease by growing new blood vessels in this animated video which shows our theory of our blood vessels grow, reestablish blood flow to dopamine producing regions of the brain, thereby increasing dopamine production in the brain, and relieving the symptoms of Parkinson’s Disease.

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